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In Vitro and In Vivo Activity of Multi-Target Inhibitors Against Trypanosoma brucei
We tested a series of amidine and related compounds against Trypanosoma brucei. The most active compound was a biphenyldiamidine which had an EC(50) of 7.7 nM against bloodstream form parasites. There was little toxicity against two human cell lines with CC(50) > 100 μM. There was also good in vi...
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| Publicado no: | ACS Infect Dis |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4539249/ https://ncbi.nlm.nih.gov/pubmed/26295062 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.5b00068 |
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