In Vitro and In Vivo Investigation of the Inhibition of Trypanosoma brucei Cell Growth by Lipophilic Bisphosphonates

We report the results of a screen of a library of 925 potential prenyl synthase inhibitors against Trypanosoma brucei farnesyl diphosphate synthase (TbFPPS) and against T. brucei, the causative agent of human African trypanosomiasis. The most potent compounds were lipophilic analogs of the bone reso...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Yang, Gyongseon, Zhu, Wei, Kim, Kuglae, Byun, Soo Young, Choi, Gahee, Wang, Ke, Cha, Jeong Seok, Cho, Hyun-Soo, Oldfield, Eric, No, Joo Hwan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649187/
https://ncbi.nlm.nih.gov/pubmed/26392508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01873-15
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