In Vitro and In Vivo Investigation of the Inhibition of Trypanosoma brucei Cell Growth by Lipophilic Bisphosphonates

We report the results of a screen of a library of 925 potential prenyl synthase inhibitors against Trypanosoma brucei farnesyl diphosphate synthase (TbFPPS) and against T. brucei, the causative agent of human African trypanosomiasis. The most potent compounds were lipophilic analogs of the bone reso...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Yang, Gyongseon, Zhu, Wei, Kim, Kuglae, Byun, Soo Young, Choi, Gahee, Wang, Ke, Cha, Jeong Seok, Cho, Hyun-Soo, Oldfield, Eric, No, Joo Hwan
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2015
Soggetti:
Experimental Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649187/
https://ncbi.nlm.nih.gov/pubmed/26392508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01873-15
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