Pregnane X Receptor–Humanized Mice Recapitulate Gender Differences in Ethanol Metabolism but Not Hepatotoxicity

Both human and rodent females are more susceptible to developing alcoholic liver disease following chronic ethanol (EtOH) ingestion. However, little is known about the relative effects of acute EtOH exposure on hepatotoxicity in female versus male mice. The nuclear receptor pregnane X receptor (PXR;...

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Udgivet i:J Pharmacol Exp Ther
Main Authors: Spruiell, Krisstonia, Gyamfi, Afua A., Yeyeodu, Susan T., Richardson, Ricardo M., Gonzalez, Frank J., Gyamfi, Maxwell A.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2015
Fag:
Gastrointestinal, Hepatic, Pulmonary, and Renal
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538875/
https://ncbi.nlm.nih.gov/pubmed/26159875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.224295
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