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Milk Thistle Constituents Inhibit Raloxifene Intestinal Glucuronidation: A Potential Clinically Relevant Natural Product–Drug Interaction

Women at high risk of developing breast cancer are prescribed selective estrogen response modulators, including raloxifene, as chemoprevention. Patients often seek complementary and alternative treatment modalities, including herbal products, to supplement prescribed medications. Milk thistle prepar...

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Detalhes bibliográficos
Publicado no:Drug Metab Dispos
Main Authors: Gufford, Brandon T., Chen, Gang, Vergara, Ana G., Lazarus, Philip, Oberlies, Nicholas H., Paine, Mary F.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538855/
https://ncbi.nlm.nih.gov/pubmed/26070840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.065086
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