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Identification of Diet-Derived Constituents as Potent Inhibitors of Intestinal Glucuronidation

Drug-metabolizing enzymes within enterocytes constitute a key barrier to xenobiotic entry into the systemic circulation. Furanocoumarins in grapefruit juice are cornerstone examples of diet-derived xenobiotics that perpetrate interactions with drugs via mechanism-based inhibition of intestinal CYP3A...

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Bibliografiske detaljer
Main Authors: Gufford, Brandon T., Chen, Gang, Lazarus, Philip, Graf, Tyler N., Oberlies, Nicholas H., Paine, Mary F.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4164973/
https://ncbi.nlm.nih.gov/pubmed/25008344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.114.059451
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