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Identification of Diet-Derived Constituents as Potent Inhibitors of Intestinal Glucuronidation
Drug-metabolizing enzymes within enterocytes constitute a key barrier to xenobiotic entry into the systemic circulation. Furanocoumarins in grapefruit juice are cornerstone examples of diet-derived xenobiotics that perpetrate interactions with drugs via mechanism-based inhibition of intestinal CYP3A...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The American Society for Pharmacology and Experimental Therapeutics
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4164973/ https://ncbi.nlm.nih.gov/pubmed/25008344 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.114.059451 |
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