TET1 is controlled by pluripotency-associated factors in ESCs and downmodulated by PRC2 in differentiated cells and tissues

Ten-eleven translocation (Tet) genes encode for a family of hydroxymethylase enzymes involved in regulating DNA methylation dynamics. Tet1 is highly expressed in mouse embryonic stem cells (ESCs) where it plays a critical role the pluripotency maintenance. Tet1 is also involved in cell reprogramming...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Neri, Francesco, Incarnato, Danny, Krepelova, Anna, Dettori, Daniela, Rapelli, Stefania, Maldotti, Mara, Parlato, Caterina, Anselmi, Francesca, Galvagni, Federico, Oliviero, Salvatore
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538807/
https://ncbi.nlm.nih.gov/pubmed/25925565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv392
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