Genome-wide analysis identifies a functional association of Tet1 and Polycomb repressive complex 2 in mouse embryonic stem cells

BACKGROUND: Ten-Eleven Translocation (TETs)proteins mediate the oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Tet1 is expressed at high levels in mouse embryonic stem cells (ESCs), where it mediates the induction of 5hmC decoration on gene-regulatory elements. While the func...

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Autors principals: Neri, Francesco, Incarnato, Danny, Krepelova, Anna, Rapelli, Stefania, Pagnani, Andrea, Zecchina, Riccardo, Parlato, Caterina, Oliviero, Salvatore
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2013
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053938/
https://ncbi.nlm.nih.gov/pubmed/23987249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2013-14-8-r91
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