PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not naïve ESCs

Polycomb repressive complex 2 and the epigenetic mark that it deposits, H3K27me3, are evolutionarily conserved and play critical roles in development and cancer. However, their roles in cell fate decisions in early embryonic development remain poorly understood. Here we report that knockout of polyc...

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Publicado no:Nat Commun
Main Authors: Shan, Yongli, Liang, Zechuan, Xing, Qi, Zhang, Tian, Wang, Bo, Tian, Shulan, Huang, Wenhao, Zhang, Yanqi, Yao, Jiao, Zhu, Yanling, Huang, Ke, Liu, Yujian, Wang, Xiaoshan, Chen, Qianyu, Zhang, Jian, Shang, Bizhi, Li, Shengbiao, Shi, Xi, Liao, Baojian, Zhang, Cong, Lai, Keyu, Zhong, Xiaofen, Shu, Xiaodong, Wang, Jinyong, Yao, Hongjie, Chen, Jiekai, Pei, Duanqing, Pan, Guangjin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5610324/
https://ncbi.nlm.nih.gov/pubmed/28939884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00668-4
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