PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not naïve ESCs

Polycomb repressive complex 2 and the epigenetic mark that it deposits, H3K27me3, are evolutionarily conserved and play critical roles in development and cancer. However, their roles in cell fate decisions in early embryonic development remain poorly understood. Here we report that knockout of polyc...

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Vydáno v:Nat Commun
Hlavní autoři: Shan, Yongli, Liang, Zechuan, Xing, Qi, Zhang, Tian, Wang, Bo, Tian, Shulan, Huang, Wenhao, Zhang, Yanqi, Yao, Jiao, Zhu, Yanling, Huang, Ke, Liu, Yujian, Wang, Xiaoshan, Chen, Qianyu, Zhang, Jian, Shang, Bizhi, Li, Shengbiao, Shi, Xi, Liao, Baojian, Zhang, Cong, Lai, Keyu, Zhong, Xiaofen, Shu, Xiaodong, Wang, Jinyong, Yao, Hongjie, Chen, Jiekai, Pei, Duanqing, Pan, Guangjin
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5610324/
https://ncbi.nlm.nih.gov/pubmed/28939884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00668-4
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