Antagonism between the transcription factors NANOG and OTX2 specifies rostral or caudal cell fate during neural patterning transition

During neurogenesis, neural patterning is a critical step during which neural progenitor cells differentiate into neurons with distinct functions. However, the molecular determinants that regulate neural patterning remain poorly understood. Here we optimized the “dual SMAD inhibition” method to spec...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Su, Zhenghui, Zhang, Yanqi, Liao, Baojian, Zhong, Xiaofen, Chen, Xin, Wang, Haitao, Guo, Yiping, Shan, Yongli, Wang, Lihui, Pan, Guangjin
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2018
Ämnen:
Cell Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5868256/
https://ncbi.nlm.nih.gov/pubmed/29386354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.815449
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