Antagonism between the transcription factors NANOG and OTX2 specifies rostral or caudal cell fate during neural patterning transition

During neurogenesis, neural patterning is a critical step during which neural progenitor cells differentiate into neurons with distinct functions. However, the molecular determinants that regulate neural patterning remain poorly understood. Here we optimized the “dual SMAD inhibition” method to spec...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Su, Zhenghui, Zhang, Yanqi, Liao, Baojian, Zhong, Xiaofen, Chen, Xin, Wang, Haitao, Guo, Yiping, Shan, Yongli, Wang, Lihui, Pan, Guangjin
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2018
Teme:
Cell Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5868256/
https://ncbi.nlm.nih.gov/pubmed/29386354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.815449
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