Functional Antagonism between OTX2 and NANOG Specifies a Spectrum of Heterogeneous Identities in Embryonic Stem Cells

Embryonic stem cells (ESCs) cultured in leukemia inhibitory factor (LIF) plus fetal bovine serum (FBS) exhibit heterogeneity in the expression of naive and primed transcription factors. This heterogeneity reflects the dynamic condition of ESCs and their versatility to promptly respond to signaling e...

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Udgivet i:Stem Cell Reports
Main Authors: Acampora, Dario, Di Giovannantonio, Luca Giovanni, Garofalo, Arcomaria, Nigro, Vincenzo, Omodei, Daniela, Lombardi, Alessia, Zhang, Jingchao, Chambers, Ian, Simeone, Antonio
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935799/
https://ncbi.nlm.nih.gov/pubmed/29056334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.09.019
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