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Functional Antagonism between OTX2 and NANOG Specifies a Spectrum of Heterogeneous Identities in Embryonic Stem Cells

Embryonic stem cells (ESCs) cultured in leukemia inhibitory factor (LIF) plus fetal bovine serum (FBS) exhibit heterogeneity in the expression of naive and primed transcription factors. This heterogeneity reflects the dynamic condition of ESCs and their versatility to promptly respond to signaling e...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Acampora, Dario, Di Giovannantonio, Luca Giovanni, Garofalo, Arcomaria, Nigro, Vincenzo, Omodei, Daniela, Lombardi, Alessia, Zhang, Jingchao, Chambers, Ian, Simeone, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935799/
https://ncbi.nlm.nih.gov/pubmed/29056334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.09.019
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