Vitamin C–dependent lysine demethylase 6 (KDM6)-mediated demethylation promotes a chromatin state that supports the endothelial-to-hematopoietic transition

Hematopoietic stem cells (HSCs)/progenitor cells (HPCs) are generated from hemogenic endothelial cells (HECs) during the endothelial-to-hematopoietic transition (EHT); however, the underlying mechanism remains poorly understood. Here, using an array of approaches, including CRSPR/Cas9 gene knockouts...

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Vydáno v:J Biol Chem
Hlavní autoři: Zhang, Tian, Huang, Ke, Zhu, Yanling, Wang, Tianyu, Shan, Yongli, Long, Bing, Li, Yuhang, Chen, Qianyu, Wang, Pengtao, Zhao, Shaoyang, Li, Dongwei, Wu, Chuman, Kang, Baoqiang, Gu, Jiaming, Mai, Yuchan, Wang, Qing, Li, Jinbing, Zhang, Yanqi, Liang, Zechuan, Guo, Lin, Wu, Fang, Su, Shuquan, Wang, Junwei, Gao, Minghui, Zhong, Xiaofen, Liao, Baojian, Chen, Jiekai, Zhang, Xiao, Shu, Xiaodong, Pei, Duanqing, Nie, Jinfu, Pan, Guangjin
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6746450/
https://ncbi.nlm.nih.gov/pubmed/31341023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009757
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