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Mutations in a translation initiation factor identify target of a memory-enhancing compound
The integrated stress response (ISR) modulates mRNA translation to regulate the mammalian unfolded protein response (UPR), immunity and memory formation. A chemical ISR inhibitor, ISRIB, enhances cognitive function and modulates the UPR in vivo. To explore mechanisms involved in ISRIB action we scre...
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| 出版年: | Science |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4538794/ https://ncbi.nlm.nih.gov/pubmed/25858979 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaa6986 |
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