Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor, eIF2B

The Integrated Stress Response (ISR) is a conserved translational and transcriptional program affecting metabolism, memory and immunity. The ISR is mediated by stress-induced phosphorylation of translation initiation factor 2α (eIF2α) that attenuates the guanine nucleotide exchange factor eIF2B. A c...

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Vydáno v:Science
Hlavní autoři: Zyryanova, Alisa F., Weis, Félix, Faille, Alexandre, Alard, Akeel Abo, Crespillo-Casado, Ana, Sekine, Yusuke, Harding, Heather P., Allen, Felicity, Parts, Leopold, Fromont, Christophe, Fischer, Peter M., Warren, Alan J., Ron, David
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5889100/
https://ncbi.nlm.nih.gov/pubmed/29599245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aar5129
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