Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor, eIF2B

The Integrated Stress Response (ISR) is a conserved translational and transcriptional program affecting metabolism, memory and immunity. The ISR is mediated by stress-induced phosphorylation of translation initiation factor 2α (eIF2α) that attenuates the guanine nucleotide exchange factor eIF2B. A c...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Science
Main Authors: Zyryanova, Alisa F., Weis, Félix, Faille, Alexandre, Alard, Akeel Abo, Crespillo-Casado, Ana, Sekine, Yusuke, Harding, Heather P., Allen, Felicity, Parts, Leopold, Fromont, Christophe, Fischer, Peter M., Warren, Alan J., Ron, David
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5889100/
https://ncbi.nlm.nih.gov/pubmed/29599245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aar5129
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados