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Mutations in a translation initiation factor identify target of a memory-enhancing compound
The integrated stress response (ISR) modulates mRNA translation to regulate the mammalian unfolded protein response (UPR), immunity and memory formation. A chemical ISR inhibitor, ISRIB, enhances cognitive function and modulates the UPR in vivo. To explore mechanisms involved in ISRIB action we scre...
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| Publicado no: | Science |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4538794/ https://ncbi.nlm.nih.gov/pubmed/25858979 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaa6986 |
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