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Sequential ubiquitination and deubiquitination enzymes synchronize the dual sensor and effector functions of TRIM21
Tripartite motif (TRIM) 21 is a cytosolic antibody receptor that neutralizes antibody-coated viruses that penetrate the cell and simultaneously activates innate immunity. Here we show that the conjugation of TRIM21 with K63-linked ubiquitin (Ub-(63)Ub) catalyzed by the sequential activity of nonredu...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4538650/ https://ncbi.nlm.nih.gov/pubmed/26150489 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1507534112 |
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