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Inactive conformation enhances binding function in physiological conditions
Many receptors display conformational flexibility, in which the binding pocket has an open inactive conformation in the absence of ligand and a tight active conformation when bound to ligand. Here we study the bacterial adhesin FimH to address the role of the inactive conformation of the pocket for...
Shranjeno v:
| izdano v: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4538629/ https://ncbi.nlm.nih.gov/pubmed/26216967 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1503160112 |
| Oznake: |
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