FimH Forms Catch Bonds That Are Enhanced by Mechanical Force Due to Allosteric Regulation

The bacterial adhesive protein, FimH, is the most common adhesin of Escherichia coli and mediates weak adhesion at low flow but strong adhesion at high flow. There is evidence that this occurs because FimH forms catch bonds, defined as bonds that are strengthened by tensile mechanical force. Here, w...

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Detalhes bibliográficos
Main Authors: Yakovenko, Olga, Sharma, Shivani, Forero, Manu, Tchesnokova, Veronika, Aprikian, Pavel, Kidd, Brian, Mach, Albert, Vogel, Viola, Sokurenko, Evgeni, Thomas, Wendy E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2431072/
https://ncbi.nlm.nih.gov/pubmed/18292092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M707815200
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