FimH Forms Catch Bonds That Are Enhanced by Mechanical Force Due to Allosteric Regulation

The bacterial adhesive protein, FimH, is the most common adhesin of Escherichia coli and mediates weak adhesion at low flow but strong adhesion at high flow. There is evidence that this occurs because FimH forms catch bonds, defined as bonds that are strengthened by tensile mechanical force. Here, w...

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Autores principales: Yakovenko, Olga, Sharma, Shivani, Forero, Manu, Tchesnokova, Veronika, Aprikian, Pavel, Kidd, Brian, Mach, Albert, Vogel, Viola, Sokurenko, Evgeni, Thomas, Wendy E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
Materias:
Protein Structure and Folding
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2431072/
https://ncbi.nlm.nih.gov/pubmed/18292092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M707815200
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