Tight Conformational Coupling between the Domains of the Enterotoxigenic Escherichia coli Fimbrial Adhesin CfaE Regulates Binding State Transition

CfaE, the tip adhesin of enterotoxigenic Escherichia coli colonization factor antigen I fimbriae, initiates binding of this enteropathogen to the small intestine. It comprises stacked β-sandwich adhesin (AD) and pilin (PD) domains, with the putative receptor-binding pocket at one pole and an equator...

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Main Authors: Liu, Yang, Esser, Lothar, Interlandi, Gianluca, Kisiela, Dagmara I., Tchesnokova, Veronika, Thomas, Wendy E., Sokurenko, Evgeni, Xia, Di, Savarino, Stephen J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Microbiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617298/
https://ncbi.nlm.nih.gov/pubmed/23393133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.413534
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