Conformational inactivation induces immunogenicity of the receptor-binding pocket of a bacterial adhesin

Inhibiting antibodies targeting receptor-binding pockets in proteins is a major focus in the development of vaccines and in antibody-based therapeutic strategies. Here, by using a common mannose-specific fimbrial adhesin of Escherichia coli, FimH, we demonstrate that locking the adhesin in a low-bin...

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Bibliographic Details
Main Authors: Kisiela, Dagmara I., Rodriguez, Victoria B., Tchesnokova, Veronika, Avagyan, Hovhannes, Aprikian, Pavel, Liu, Yan, Wu, Xue-Ru, Thomas, Wendy E., Sokurenko, Evgeni V.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2013
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3839742/
https://ncbi.nlm.nih.gov/pubmed/24191044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1314395110
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