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Conformational inactivation induces immunogenicity of the receptor-binding pocket of a bacterial adhesin
Inhibiting antibodies targeting receptor-binding pockets in proteins is a major focus in the development of vaccines and in antibody-based therapeutic strategies. Here, by using a common mannose-specific fimbrial adhesin of Escherichia coli, FimH, we demonstrate that locking the adhesin in a low-bin...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3839742/ https://ncbi.nlm.nih.gov/pubmed/24191044 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1314395110 |
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