Conformational inactivation induces immunogenicity of the receptor-binding pocket of a bacterial adhesin

Inhibiting antibodies targeting receptor-binding pockets in proteins is a major focus in the development of vaccines and in antibody-based therapeutic strategies. Here, by using a common mannose-specific fimbrial adhesin of Escherichia coli, FimH, we demonstrate that locking the adhesin in a low-bin...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Kisiela, Dagmara I., Rodriguez, Victoria B., Tchesnokova, Veronika, Avagyan, Hovhannes, Aprikian, Pavel, Liu, Yan, Wu, Xue-Ru, Thomas, Wendy E., Sokurenko, Evgeni V.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2013
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3839742/
https://ncbi.nlm.nih.gov/pubmed/24191044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1314395110
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk