Toggle switch residues control allosteric transitions in bacterial adhesins by participating in a concerted repacking of the protein core

Critical molecular events that control conformational transitions in most allosteric proteins are ill-defined. The mannose-specific FimH protein of Escherichia coli is a prototypic bacterial adhesin that switches from an ‘inactive’ low-affinity state (LAS) to an ‘active’ high-affinity state (HAS) co...

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Pubblicato in:PLoS Pathog
Autori principali: Kisiela, Dagmara I., Magala, Pearl, Interlandi, Gianluca, Carlucci, Laura A., Ramos, Angelo, Tchesnokova, Veronika, Basanta, Benjamin, Yarov-Yarovoy, Vladimir, Avagyan, Hovhannes, Hovhannisyan, Anahit, Thomas, Wendy E., Stenkamp, Ronald E., Klevit, Rachel E., Sokurenko, Evgeni V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8064603/
https://ncbi.nlm.nih.gov/pubmed/33826682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009440
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