Cellular Pharmacokinetics and Intracellular Activity of the Novel Peptide Deformylase Inhibitor GSK1322322 against Staphylococcus aureus Laboratory and Clinical Strains with Various Resistance Phenotypes: Studies with Human THP-1 Monocytes and J774 Murine Macrophages

GSK1322322 is a peptide deformylase inhibitor active against Staphylococcus aureus strains resistant to currently marketed antibiotics. Our aim was to assess the activity of GSK1322322 against intracellular S. aureus using an in vitro pharmacodynamic model and, in parallel, to examine its cellular p...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Principais autores: Peyrusson, Frédéric, Butler, Deborah, Tulkens, Paul M., Van Bambeke, Françoise
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538490/
https://ncbi.nlm.nih.gov/pubmed/26169402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00827-15
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