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Cellular Pharmacokinetics and Intracellular Activity of Gepotidacin against Staphylococcus aureus Isolates with Different Resistance Phenotypes in Models of Cultured Phagocytic Cells

Gepotidacin (GSK2140944), a novel triazaacenaphthylene bacterial topoisomerase inhibitor, is currently in clinical development for the treatment of bacterial infections. This study examined in vitro its activity against intracellular Staphylococcus aureus (involved in the persistent character of ski...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Peyrusson, Frédéric, Tulkens, Paul M., Van Bambeke, Françoise
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5913948/
https://ncbi.nlm.nih.gov/pubmed/29358297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02245-17
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