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Cellular Pharmacokinetics of the Novel Biaryloxazolidinone Radezolid in Phagocytic Cells: Studies with Macrophages and Polymorphonuclear Neutrophils

Radezolid (RX-1741) is the first biaryloxazolidinone in clinical development. It shows improved activity, including against linezolid-resistant strains. Radezolid differs from linezolid by the presence of a biaryl spacer and of a heteroaryl side chain, which increases the ionization and hydrophilici...

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Hlavní autoři: Lemaire, Sandrine, Tulkens, Paul M., Van Bambeke, Françoise
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876419/
https://ncbi.nlm.nih.gov/pubmed/20385873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01723-09
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