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Cellular Accumulation and Pharmacodynamic Evaluation of the Intracellular Activity of CEM-101, a Novel Fluoroketolide, against Staphylococcus aureus, Listeria monocytogenes, and Legionella pneumophila in Human THP-1 Macrophages

CEM-101 is a novel fluoroketolide with lower MICs than those of telithromycin and macrolides. Our aim was to assess the cellular accumulation and intracellular activity of CEM-101 using models developed for analyzing the pharmacokinetics and pharmacological properties of antibiotics against phagocyt...

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Autors principals: Lemaire, Sandrine, Van Bambeke, Françoise, Tulkens, Paul M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737860/
https://ncbi.nlm.nih.gov/pubmed/19564365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00203-09
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