Cellular Pharmacokinetics and Intracellular Activity of the Novel Peptide Deformylase Inhibitor GSK1322322 against Staphylococcus aureus Laboratory and Clinical Strains with Various Resistance Phenotypes: Studies with Human THP-1 Monocytes and J774 Murine Macrophages

GSK1322322 is a peptide deformylase inhibitor active against Staphylococcus aureus strains resistant to currently marketed antibiotics. Our aim was to assess the activity of GSK1322322 against intracellular S. aureus using an in vitro pharmacodynamic model and, in parallel, to examine its cellular p...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Antimicrob Agents Chemother
Egile Nagusiak: Peyrusson, Frédéric, Butler, Deborah, Tulkens, Paul M., Van Bambeke, Françoise
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2015
Gaiak:
Pharmacology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538490/
https://ncbi.nlm.nih.gov/pubmed/26169402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00827-15
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