A combination hydrogel microparticle-based vaccine prevents type 1 diabetes in non-obese diabetic mice

Targeted delivery of self-antigens to the immune system in a mode that stimulates a tolerance-inducing pathway has proven difficult. To address this hurdle, we developed a vaccine based-approach comprised of two synthetic controlled-release biomaterials, poly(lactide-co-glycolide; PLGA) microparticl...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Yoon, Young Mee, Lewis, Jamal S., Carstens, Matthew R., Campbell-Thompson, Martha, Wasserfall, Clive H., Atkinson, Mark A., Keselowsky, Benjamin G.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538389/
https://ncbi.nlm.nih.gov/pubmed/26279095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep13155
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