Immunomodulatory Dual-Sized Microparticle System Conditions Human Antigen Presenting Cells Into a Tolerogenic Phenotype In Vitro and Inhibits Type 1 Diabetes-Specific Autoreactive T Cell Responses

Current monotherapeutic agents fail to restore tolerance to self-antigens in autoimmune individuals without systemic immunosuppression. We hypothesized that a combinatorial drug formulation delivered by a poly-lactic-co-glycolic acid (PLGA) dual-sized microparticle (dMP) system would facilitate tuna...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Brusko, Maigan A., Stewart, Joshua M., Posgai, Amanda L., Wasserfall, Clive H., Atkinson, Mark A., Brusko, Todd M., Keselowsky, Benjamin G.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7649824/
https://ncbi.nlm.nih.gov/pubmed/33193362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.574447
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