A combination dual-sized microparticle system modulates dendritic cells and prevents type 1 diabetes in prediabetic NOD mice

We developed a novel poly(lactic-co-glycolic acid)-based, microparticle (MP) system providing concurrent delivery of multiple encapsulated immuno-suppressive factors and antigen, for in vivo conditioning of dendritic cells (DCs) toward a tolerance promoting pathway. Subcutaneous administration preve...

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Publicado en:Clin Immunol
Autores principales: Lewis, Jamal S., Dolgova, Natalia V., Zhang, Ying, Xia, Chang Qing, Wasserfall, Clive H., Atkinson, Mark A., Clare-Salzler, Michael J., Keselowsky, Benjamin G.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4554803/
https://ncbi.nlm.nih.gov/pubmed/25842187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2015.03.023
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