IFN-γ-induced JAK/STAT, but not NF-κB, signaling pathway is insensitive to glucocorticoid in airway epithelial cells

Although the majority of patients with asthma are well controlled by inhaled glucocorticoids (GCs), patients with severe asthma are poorly responsive to GCs. This latter group is responsible for a disproportionate share of health care costs associated with asthma. Recent studies in immune cells have...

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Udgivet i:Am J Physiol Lung Cell Mol Physiol
Main Authors: O'Connell, Danielle, Bouazza, Belaid, Kokalari, Blerina, Amrani, Yassine, Khatib, Alaa, Ganther, John David, Tliba, Omar
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2015
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538237/
https://ncbi.nlm.nih.gov/pubmed/26092996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00099.2015
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