RAG Represents a Widespread Threat to the Lymphocyte Genome

The RAG1 endonuclease, together with its cofactor RAG2, is essential for V(D)J recombination but is a potent threat to genome stability. The sources of RAG1 mis-targeting and the mechanisms that have evolved to suppress it are poorly understood. Here, we report that RAG1 associates with chromatin at...

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Veröffentlicht in:Cell
Hauptverfasser: Teng, Grace, Maman, Yaakov, Resch, Wolfgang, Kim, Min, Yamane, Arito, Qian, Jason, Kieffer-Kwon, Kyong-Rim, Mandal, Malay, Ji, Yanhong, Meffre, Eric, Clark, Marcus R., Cowell, Lindsay G., Casellas, Rafael, Schatz, David G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537821/
https://ncbi.nlm.nih.gov/pubmed/26234156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.07.009
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