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RAG Represents a Widespread Threat to the Lymphocyte Genome
The RAG1 endonuclease, together with its cofactor RAG2, is essential for V(D)J recombination but is a potent threat to genome stability. The sources of RAG1 mis-targeting and the mechanisms that have evolved to suppress it are poorly understood. Here, we report that RAG1 associates with chromatin at...
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| Опубликовано в: : | Cell |
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| Главные авторы: | , , , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4537821/ https://ncbi.nlm.nih.gov/pubmed/26234156 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.07.009 |
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