Widespread Transient Hoogsteen Base-Pairs in Canonical Duplex DNA with Variable Energetics

Hoogsteen base-pairing involves a 180 degree rotation of the purine base relative to Watson-Crick base-pairing within DNA duplexes, creating alternative DNA conformations that can play roles in recognition, damage induction, and replication. Here, using Nuclear Magnetic Resonance R(1ρ) relaxation di...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Alvey, Heidi S., Gottardo, Federico L., Nikolova, Evgenia N., Al-Hashimi, Hashim M.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537320/
https://ncbi.nlm.nih.gov/pubmed/25185517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5786
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