Preparation of fluorinated RNA nucleotide analogs potentially stable to enzymatic hydrolysis in RNA and DNA polymerase assays

Analogs of ribonucleotides (RNA) stable to enzymatic hydrolysis were prepared and characterized. Computational investigations revealed that this class of compounds with a modified triphosphate exhibits the correct polarity and minimal steric effects compared to the natural molecule. Non-hydrolysable...

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Библиографические подробности
Опубликовано в: :J Fluor Chem
Главные авторы: Shakhmin, Anton, Jones, John-Paul, Bychinskaya, Inessa, Zibinsky, Mikhail, Oertell, Keriann, Goodman, Myron F., Prakash, G.K. Surya
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536853/
https://ncbi.nlm.nih.gov/pubmed/26279588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jfluchem.2014.07.019
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