Preparation of fluorinated RNA nucleotide analogs potentially stable to enzymatic hydrolysis in RNA and DNA polymerase assays

Analogs of ribonucleotides (RNA) stable to enzymatic hydrolysis were prepared and characterized. Computational investigations revealed that this class of compounds with a modified triphosphate exhibits the correct polarity and minimal steric effects compared to the natural molecule. Non-hydrolysable...

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發表在:J Fluor Chem
Main Authors: Shakhmin, Anton, Jones, John-Paul, Bychinskaya, Inessa, Zibinsky, Mikhail, Oertell, Keriann, Goodman, Myron F., Prakash, G.K. Surya
格式: Artigo
語言:Inglês
出版: 2014
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536853/
https://ncbi.nlm.nih.gov/pubmed/26279588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jfluchem.2014.07.019
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