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Histone deacetylase inhibition protects hearing against acute ototoxicity by activating the Nf-κB pathway
Auditory hair cells have repeatedly been shown to be susceptible to ototoxicity from a multitude of drugs including aminoglycoside antibiotics. Here, we found that systemic HDAC inhibition using suberoylanilide hydroxamic acid (SAHA) on adult mice offers almost complete protection against hair cell...
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| Publicat a: | Cell Death Discov |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4536828/ https://ncbi.nlm.nih.gov/pubmed/26279947 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddiscovery.2015.12 |
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