Histone deacetylase inhibition protects hearing against acute ototoxicity by activating the Nf-κB pathway

Auditory hair cells have repeatedly been shown to be susceptible to ototoxicity from a multitude of drugs including aminoglycoside antibiotics. Here, we found that systemic HDAC inhibition using suberoylanilide hydroxamic acid (SAHA) on adult mice offers almost complete protection against hair cell...

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Detaylı Bibliyografya
Yayımlandı:Cell Death Discov
Asıl Yazarlar: Layman, W S, Williams, D M, Dearman, J A, Sauceda, M A, Zuo, J
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536828/
https://ncbi.nlm.nih.gov/pubmed/26279947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddiscovery.2015.12
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