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Histone deacetylase inhibition protects hearing against acute ototoxicity by activating the Nf-κB pathway
Auditory hair cells have repeatedly been shown to be susceptible to ototoxicity from a multitude of drugs including aminoglycoside antibiotics. Here, we found that systemic HDAC inhibition using suberoylanilide hydroxamic acid (SAHA) on adult mice offers almost complete protection against hair cell...
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| Опубликовано в: : | Cell Death Discov |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4536828/ https://ncbi.nlm.nih.gov/pubmed/26279947 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddiscovery.2015.12 |
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