Histone deacetylase inhibition protects hearing against acute ototoxicity by activating the Nf-κB pathway

Auditory hair cells have repeatedly been shown to be susceptible to ototoxicity from a multitude of drugs including aminoglycoside antibiotics. Here, we found that systemic HDAC inhibition using suberoylanilide hydroxamic acid (SAHA) on adult mice offers almost complete protection against hair cell...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Death Discov
Egile Nagusiak: Layman, W S, Williams, D M, Dearman, J A, Sauceda, M A, Zuo, J
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536828/
https://ncbi.nlm.nih.gov/pubmed/26279947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddiscovery.2015.12
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