Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.

Nonsteroidal antiinflammatory drugs (NSAIDs) are widely used for the treatment of inflammatory diseases, but significant side effects such as gastrointestinal erosion and renal damage limit their use. NSAIDs inhibit the enzyme cyclooxygenase (COX), which catalyzes the conversion of arachidonic acid...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Seibert, K, Zhang, Y, Leahy, K, Hauser, S, Masferrer, J, Perkins, W, Lee, L, Isakson, P
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45366/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7991575/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.25.12013
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