Methylation-independent repression of Dnmt3b contributes to oncogenic activity of Dnmt3a in mouse MYC-induced T-cell lymphomagenesis

DNA methyltransferase 3A (DNMT3A) catalyzes cytosine methylation of mammalian genomic DNA. In addition to myeloid malignancies, mutations in DNMT3A have been recently reported in T-cell lymphoma and leukemia, implying a possible involvement in the pathogenesis of human diseases. However, the role of...

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Pubblicato in:Oncogene
Autori principali: Haney, Staci L., Hlady, Ryan A., Opavska, Jana, Klinkebiel, David, Pirruccello, Samuel J., Dutta, Samikshan, Datta, Kaustubh, Simpson, Melanie A., Wu, Lizhao, Opavsky, Rene
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4533871/
https://ncbi.nlm.nih.gov/pubmed/25639876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.472
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