Splenectomy Protects against Sepsis Lethality and Reduces Serum HMGB1 Levels()

High mobility group box 1 (HMGB1) is a critical mediator of lethal sepsis. Previously, we showed that apoptotic cells can activate macrophages to release HMGB1. During sepsis, apoptosis occurs primarily in lymphoid organs, including the spleen and thymus. Currently, it is unclear whether this accele...

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Veröffentlicht in:J Immunol
Hauptverfasser: Huston, Jared M., Wang, Haichao, Ochani, Mahendar, Ochani, Kanta, Rosas-Ballina, Mauricio, Gallowitsch-Puerta, Margot, Ashok, Mala, Yang, Lihong, Tracey, Kevin J., Yang, Huan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4533852/
https://ncbi.nlm.nih.gov/pubmed/18714026
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