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Central muscarinic cholinergic regulation of the systemic inflammatory response during endotoxemia

TNF has a critical mediator role in inflammation and is an important therapeutic target. We recently discovered that TNF production is regulated by neural signals through the vagus nerve. Activation of this “cholinergic antiinflammatory pathway” inhibits the production of TNF and other cytokines and...

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Main Authors: Pavlov, Valentin A., Ochani, Mahendar, Gallowitsch-Puerta, Margot, Ochani, Kanta, Huston, Jared M., Czura, Christopher J., Al-Abed, Yousef, Tracey, Kevin J.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2006
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1405626/
https://ncbi.nlm.nih.gov/pubmed/16549778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600506103
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