Disruption of the PHRF1 Tumor Suppressor Network by PML-RARα Drives Acute Promyelocytic Leukemia Pathogenesis

PHRF1 functions as an essential component of the TGF-β tumor suppressor pathway by triggering degradation of the homeodomain transcription factor TGIF. This leads to redistribution of cPML into the cytoplasm, where it coordinates phosphorylation and activation of Smad2 by the TGF-β receptor. In acut...

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Pubblicato in:Cell Rep
Autori principali: Prunier, Céline, Zhang, Ming-Zhu, Kumar, Santosh, Levy, Laurence, Ferrigno, Olivier, Tzivion, Guri, Atfi, Azeddine
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532664/
https://ncbi.nlm.nih.gov/pubmed/25683711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.01.024
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