Functional Characterization of a WWP1/Tiul1 Tumor-derived Mutant Reveals a Paradigm of Its Constitutive Activation in Human Cancer

Although E3 ubiquitin ligases are deemed to play key roles in normal cell function and homeostasis, whether their alterations contribute to cancer pathogenesis remains unclear. In this study, we sought to investigate potential mechanisms that govern WWP1/Tiul1 (WWP1) ubiquitin ligase activity, focus...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Courivaud, Thomas, Ferrand, Nathalie, Elkhattouti, Abdelouahid, Kumar, Santosh, Levy, Laurence, Ferrigno, Olivier, Atfi, Azeddine, Prunier, Céline
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Protein Synthesis and Degradation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543659/
https://ncbi.nlm.nih.gov/pubmed/26152726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.642314
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