Disruption of the PHRF1 Tumor Suppressor Network by PML-RARα Drives Acute Promyelocytic Leukemia Pathogenesis

PHRF1 functions as an essential component of the TGF-β tumor suppressor pathway by triggering degradation of the homeodomain transcription factor TGIF. This leads to redistribution of cPML into the cytoplasm, where it coordinates phosphorylation and activation of Smad2 by the TGF-β receptor. In acut...

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Udgivet i:Cell Rep
Main Authors: Prunier, Céline, Zhang, Ming-Zhu, Kumar, Santosh, Levy, Laurence, Ferrigno, Olivier, Tzivion, Guri, Atfi, Azeddine
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532664/
https://ncbi.nlm.nih.gov/pubmed/25683711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.01.024
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