Disruption of the PHRF1 Tumor Suppressor Network by PML-RARα Drives Acute Promyelocytic Leukemia Pathogenesis

PHRF1 functions as an essential component of the TGF-β tumor suppressor pathway by triggering degradation of the homeodomain transcription factor TGIF. This leads to redistribution of cPML into the cytoplasm, where it coordinates phosphorylation and activation of Smad2 by the TGF-β receptor. In acut...

全面介紹

Na minha lista:
書目詳細資料
發表在:Cell Rep
Main Authors: Prunier, Céline, Zhang, Ming-Zhu, Kumar, Santosh, Levy, Laurence, Ferrigno, Olivier, Tzivion, Guri, Atfi, Azeddine
格式: Artigo
語言:Inglês
出版: 2015
主題:
Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532664/
https://ncbi.nlm.nih.gov/pubmed/25683711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.01.024
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!

相似書籍