Growth inhibition and induction of differentiation of t(8;21) acute myeloid leukemia cells by the DNA-binding domain of PEBP2 and the AML1/MTG8(ETO)-specific antisense oligonucleotide.
The translocation from chromosome 8 to chromosome 21, t(8;21), associated with acute myeloid leukemia results in production of an AML1/MTG8(ETO) fusion transcript. The product of the AML1 gene contains an evolutionarily conserved 128-amino acid region referred to as the "Runt domain," whic...
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Main Authors: | , , , , , , , , , |
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格式: | Artigo |
語言: | Inglês |
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1994
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在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC45304/ https://ncbi.nlm.nih.gov/pubmed/7972130 |
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